When you notice changes in your body or mind, you might be tempted to chalk it up to a bad day, getting older, or something you ate. But there are times when you need to see the doctor and seemingly minor symptoms you should never ignore.

Here are five times you should make a doctor’s appointment right away.

Sudden Weight Loss

Lots of people struggle with their weight, so when the weight suddenly comes off, your first instinct may be to accept the gift without question. That would be a mistake! If you’re not trying to lose weight and all of the sudden the weight drops off without trying, it may be a sign something is wrong.

Make a doctor’s appointment and get checked. It’s better to be safe than sorry.

Thunderclap Headaches

Getting headaches is a fairly common fact of life, and you might want to just take some Ibuprofen and go back to bed. If you get a headache unlike any you’ve ever felt before, though, get it checked. A sudden extreme headache may be a sign of an aneurysm or a slew of other medical conditions.

Not only might the doctor be able to tell you what is causing your headache, she might be able to help.

Changes In Bowel Movements

Nobody really likes to talk about what they do and don’t do in the bathroom, but each person has an idea about what’s normal for them. Changes in bowel movements, whether in frequency or consistency, can signal a bigger problem.

If your bowel movement changes last for more than a few days or blood is present, make a doctor’s appointment right away. The digestive system is very important to your overall health, so it’s important to keep it working normally.

Changes In Mental State

Sudden changes in your mental state, like aggression, confusion, or disorientation is your brain telling you something is wrong. Listen to your body, and if you notice any difference in yourself, mentally, get help immediately.

This may be a case where someone else would be a better judge of changes in you and your personality. Your loved ones should also keep an eye out for mental changes in you, and encourage you to seek help.

Persistent Fatigue

It may be normal in this day and age to feel like you’re tired all the time, but if you’re getting enough sleep and you’re still tired, see a professional.

Persistent fatigue may be a sign of an underlying condition, so don’t ignore it or drink more coffee. Make a doctor’s appointment to be sure you’re healthy.