Pizza and soda. Wine and cake. Burgers and fries. Most of us don’t ever think about what food combinations are actually good for us, but we should. Certain foods, when combined, can overload our digestive systems and cause very unpleasant gastric effects like bloating, gas, and even nausea. Here are 5 combinations to avoid.

Carbohydrates and Meat [Put Down the Burger and Fries!]

Meat and complex carbohydrates containing a lot of starch—like bread and potatoes—get digested very differently, which is why it’s a bad idea to combine them. The digestive enzymes needed to digest meat and carbs cancel each other out, often causing bloating, acid reflux, and flatulence. Waiting several hours between consuming meat and complex carbs will make digestion much easier.

Pizza and Soda

I know, it’s a go-to meal when you’re feeling lazy, but did you ever wonder why you could be only moderately hungry and still eat half a pizza in one sitting? High fructose corn syrup, found in most sodas, when added to high-carb pizza dough, actually increases hunger and decreases feelings of fullness, according to dieticians.

Fruit With Meals

It feels virtuous to skip dessert and eat fruit instead, right? Fruit is healthy, but it did you know that it can lead to indigestion if eaten during or after a meal? When you eat fruit with a meal, it gets stalled in the digestive tract and can ferment fats and proteins. This can lead to gas, lack of energy, flatulence, and bloating.

Low Fat Dressings and Salads

I know eating a salad makes you feel super healthy, but recent studies have shown that in order to get the maximum benefit from nutrition-dense vegetables, you need to also consume fats. Combining cheese or olive oil with vegetables helps the body process carotenoids like beta-carotene and lycopene. Eating vegetables without fats deprives your body. So pour on the olive oil and enjoy!

Wine and Dessert

Did you know that most wines contain quite a bit of sugar? When you combine wine with something like cake, your body can quickly get overloaded. All that sugar makes insulin levels spike and the sugar gets stored as fat. It’s a better idea to drink wine before the meal, and just have water with dessert.